COMBINED LIPIDOMIC AND PROTEOMIC ANALYSIS OF ISOLATED HUMAN ISLETS EXPOSED TO PALMITATE REVEALS TIME-DEPENDENT CHANGES IN INSULIN SECRETION AND LIPID METABOLISM.

Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion.In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specific cellular pathways or organs.Our aim was to, first

Silicone sealants have a long history of successful use in high performance windows and curtainwalls, such as structural glazing (bonding) systems which can contribute to bomb blast mitigating window designs.Previous experimental work illustrated the increase in strength and elongation for silicone sealants at the typically higher strain rates of b

We propose a model of a joint spread of heroin use and HIV infection.The unique disease-free equilibrium always exists and it is stable if the basic reproduction numbers of heroin use and HIV infection are both less than 1.The led bar mat semi-trivial equilibrium of HIV infection (heroin use) exists if the basic reproduction number of HIV infection

Abstract Hydrogels have shown great potential and value in wound healing.In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive properties to promote corneal regeneration.This hydrogel is synthesized by combining aldehyde-modifie